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Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies

Marwa F. Ahmed, Eman Y. Santali, Eman M. Mohi El-Deen, Ibrahim A. Naguib, Radwan El‐Haggar

2020Bioorganic Chemistry33 citationsDOI

Topics & Concepts

ChemistryEGFR inhibitorsErlotinibApoptosisEpidermal growth factor receptorPyridazineIC50Cell cyclePharmacologyCell cycle checkpointIn vitroErlotinib HydrochlorideDocking (animal)BiochemistryReceptorStereochemistryBiologyNursingMedicineSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsQuinazolinone synthesis and applications
Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies | Litcius