Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors
Ningyu Wang, Ying Xu, Kun-Jie Xiao, Weiqiong Zuo, Yongxia Zhu, Rong Hu, Wanli Wang, Yao-Jie Shi, Luoting Yu, Zhihao Liu
Topics & Concepts
PLK1ChemistryKinaseEpigeneticsCell growthCell cycleCancer researchIn vivoCell cycle checkpointApoptosisBiochemistryBiologyBiotechnologyGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysChromatin Remodeling and Cancer