Co-delivery of EGFR and BRD4 siRNA by cell-penetrating peptides-modified redox-responsive complex in triple negative breast cancer cells
Chi Zhang, Wen Jie Yuan, Ying Wu, Xu Wan, Yanling Gong
Topics & Concepts
Small interfering RNATransfectionGene silencingChemistryRNA interferenceViability assayTriple-negative breast cancerPI3K/AKT/mTOR pathwayMolecular biologyProtein kinase BCell growthIntracellularCancer researchCellApoptosisRNABiologyCancerBiochemistryBreast cancerGeneGeneticsRNA Interference and Gene DeliveryProtein Degradation and InhibitorsPARP inhibition in cancer therapy