PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
Jennifer L. Cannons, Alejandro V. Villarino, Senta M. Kapnick, Silvia Preite, Han‐Yu Shih, Julio Gómez‐Rodríguez, Zenia Kaul, Hirofumi Shibata, Julie Reilley, Bonnie Huang, Robin Handon, Ian McBain, Selamawit Gossa, Tuoqi Wu, Helen C. Su, Dorian B. McGavern, John J. O’Shea, Peter J. McGuire, Gülbû Uzel, Pamela L. Schwartzberg
Abstract
T cell effector differentiation, providing insight into phenotypes of patients with APDS.
Topics & Concepts
BiologyPI3K/AKT/mTOR pathwayEpigeneticsEffectorChromatinCytotoxic T cellCell biologymTORC1CD8Lymphocytic choriomeningitisCancer researchImmunologySignal transductionGeneticsImmune systemIn vitroGeneImmune Cell Function and InteractionImmunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology