The Role of CDK5 in Tumours and Tumour Microenvironments
Phuong Anh, Chang Hoon Lee
Abstract
Cyclin-dependent kinase 5 (CDK5), which belongs to the protein kinase family, regulates neuronal function but is also associated with cancer development and has been proposed as a target for cancer treatment. Indeed, CDK5 has roles in cell proliferation, apoptosis, angiogenesis, inflammation, and immune response. Aberrant CDK5 activation triggers tumour progression in numerous types of cancer. In this review, we summarise the role of CDK5 in cancer and neurons and CDK5 inhibitors. We expect that our review helps researchers to develop CDK5 inhibitors as treatments for refractory cancer.
Topics & Concepts
Cyclin-dependent kinase 5KinaseCancerCancer researchAngiogenesisInflammationApoptosisBiologyMedicineNeuroscienceImmunologyProtein kinase ACell biologyCyclin-dependent kinase 2Internal medicineBiochemistryCancer Mechanisms and TherapyLung Cancer Research StudiesCancer-related Molecular Pathways