Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma
Qianyu Shi, Jiuhui Xu, Chenglong Chen, Xueyu Hu, Boyang Wang, Fanwei Zeng, Tingting Ren, Yi Huang, Wei Guo, Xiaodong Tang, Tao Ji
Topics & Concepts
OsteosarcomaTransforming growth factorPositive feedbackCancer researchPlateletTumor progressionLoop (graph theory)ChemistryTGF beta signaling pathwayTumor cellsBiologyMedicineCell biologyImmunologyInternal medicineCancerEngineeringElectrical engineeringMathematicsCombinatoricsCell Adhesion Molecules ResearchCancer-related molecular mechanisms researchSarcoma Diagnosis and Treatment