Cancer photothermal therapy based on near infrared fluorescent CdSeTe/ZnS quantum dots
Jin Wang, Xueqiong Su, Pengxiang Zhao, Dongwen Gao, Ruixiang Chen, Li Wang
Abstract
Micro targeted therapy for cancer has become a hot topic in recent years because of its advantages of little damage to the human body and early treatment of cancer. Therefore, accurate, rapid treatment methods and biofriendly exogenous substances are extremely important. CdTeSe/ZnS core-shell quantum dots (QDs) have great potential in biomedical imaging and biological ablation therapy due to their advantages of near-infrared radiation, aqueous synthesis and bio-friendliness. In this paper, CdTeSe/ZnS core-shell QDs were prepared by aqueous synthesis, and have near infrared output and excellent photothermal properties. A blue laser was used as the irradiation source and QD fluorescence imaging can accurately calibrate the treatment area. Under the photothermal and photodynamic effects of QDs, apoptosis of hepatoma cells Huh7 was induced, which provides a new micro-nano technology and biofriendly exogenous substances for cancer treatment.