Dearomative 1,6-addition of P(O)–H to <i>in situ</i> formed <i>p</i>-QM-like ion pairs from 2-benzofuryl-ols to C3-phosphinoyl hydrobenzofurans
Long Chen, Yun‐Xiang Zou, Shi-Lu Zheng, Xiaoyan Liu, Hongli Yang, Jing Zhang, Yao Zeng, Li Duan, Zhong Wen, Hai‐Liang Ni
Abstract
We report a dearomative C3-phosphorylation and a tandem C3-phosphorylation/aromatization of 2-benzofuryl-ols with P(O)–H species to afford C3-phosphinoyl hydrobenzofurans and benzofurans, respectively.
Topics & Concepts
ChemistryAromatizationTandemIn situPhosphorylationMedicinal chemistryBiochemistryOrganic chemistryEngineeringAerospace engineeringCatalysisOrganophosphorus compounds synthesisAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and Catalysis