QbD enabled optimization of solvent shifting method for fabrication of PLGA-based nanoparticles for promising delivery of Capecitabine for antitumor activity
Goutam Kumar Jena, Chinam Niranjan Patra, Kahnu Charan Panigrahi, Sruti Jammula, Parameswar Patra, Rabinarayan Parhi
Topics & Concepts
PLGACritical quality attributesZeta potentialNanoparticleBioavailabilityMTT assayParticle sizeCapecitabineChemistryBox–Behnken designNanotechnologyDrug deliveryMaterials scienceQuality by DesignPoloxamerPolymerChromatographyResponse surface methodologyPharmacologyOrganic chemistryCell growthCancerBiochemistryColorectal cancerCopolymerPhysical chemistryMedicineInternal medicineAdvanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryDrug Solubulity and Delivery Systems