Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination
David H. Canaday, Oladayo A. Oyebanji, Debbie Keresztesy, Michael Payne, Dennis Wilk, Lenore L. Carias, Htin Aung, Kerri St. Denis, Evan C. Lam, Christopher F. Rowley, Sarah D. Berry, Cheryl Cameron, Mark J. Cameron, Brigid Wilson, Alejandro B. Balazs, Christopher L. King, Stefan Gravenstein
Abstract
Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay's limit of detection.
Topics & Concepts
MedicineVaccinationAntibodyNeutralizationSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Nursing homesCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakReduction (mathematics)Health careVirologyAntibody responseDiseaseImmunologyInternal medicineOutbreakNursingInfectious disease (medical specialty)Economic growthEconomicsGeometryMathematicsSARS-CoV-2 and COVID-19 ResearchVaccine Coverage and HesitancyInfection Control and Ventilation