Nido-carborane encapsulated by BODIPY zwitterionic polymers: Synthesis, photophysical properties and cell imaging
Chen Shao, Guangchang Lian, Guofan Jin
Abstract
Carborane encapsulation was visualized by using fluoroboropyrrole (BODIPY) zwitterionic polymer as fluorescence marker. Firstly, a water-soluble fluorescent probe carrier was prepared by combining the BODIPY derivatives with poly (carboxybetaine methacrylate) (p-CBMA). Two oil-in-water carborane polymers were self-assembled in organic solvents by means of dual ion hydrogen bonding . The ultraviolet and fluorescence spectra were measured with different organic solvents , and the spectra ranged from 531 to 555 nm. The dynamic self-assembly effect was tested by TEM , and the internal microscopic phenomena of the water-soluble polymer were further observed. It was confirmed that two kinds of BODIPY zwitterionic polymers were firmly encase the fat-soluble carborane, forming an oval shape. Carboranes are water-soluble, can achieve biocompatible expression, and can visualize the degree of aggregation in the targeted cells through its own fluorescence effect. Subsequent imaging of the cells showed that both polymers entered the targeted cells.