Highly proliferative and hypodifferentiated CAR-T cells targeting B7–H3 enhance antitumor activity against ovarian and triple-negative breast cancers
Xiaoshuai Zhang, Haiyan Guo, Jie Chen, Chenxiao Xu, Lei Wang, Yong Ke, Yang Gao, Baohong Zhang, Jianwei Zhu, Jianwei Zhu
Topics & Concepts
Chimeric antigen receptorCancer researchTriple-negative breast cancerAntigenCytotoxic T cellImmunotherapyOvarian cancerT cellBiologyCancer immunotherapyImmunologyCancerMedicineBreast cancerImmune systemInternal medicineIn vitroBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsVirus-based gene therapy research