N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction
Ashutosh Tripathi, Annadurai Thangaraj, Ernest T. Chivero, Palsamy Periyasamy, Maria Burkovetskaya, Fang Niu, Ming‐Lei Guo, Shilpa Buch
Abstract
findings, the treatment of HIV Tg rats with N-acetylcysteine also mitigated the deleterious effects of cART. Taken together, our findings suggest that oxidative stress-mediated lysosomal dysfunction plays a critical role in the pathogenesis of HAND in drug-treated HIV-infected individuals and that antioxidant-mediated mitigation of oxidative stress could thus be considered as an adjunctive therapeutic strategy for ameliorating/dampening some of the neurological complications of HAND.
Topics & Concepts
Oxidative stressAcetylcysteineAutophagyMicrogliaCartPharmacologyMedicineReactive oxygen speciesNeuroinflammationImmunologyInflammationLysosomeAntioxidantBiologyInternal medicineCell biologyBiochemistryEngineeringEnzymeApoptosisMechanical engineeringHIV Research and TreatmentNeuroinflammation and Neurodegeneration MechanismsHIV-related health complications and treatments