Zn<sup>2+</sup> improves sepsis-induced acute kidney injury by upregulating SIRT7-mediated Parkin acetylation
Jun Guo, Zhenhui Yuan, Rong Wang
Abstract
upregulated Parkin acetylation by repressing sirtuin 7 activity to promote mitophagy and inhibit NLRP3 inflammasome activation and pyroptosis, thus improving sepsis-induced acute kidney injury.
Topics & Concepts
ParkinNecroptosisAcute kidney injuryPyroptosisKidneyInflammasomeChemistrySIRT3AutophagyInflammationProgrammed cell deathMedicinePharmacologyApoptosisInternal medicineAcetylationBiochemistrySirtuinDiseaseParkinson's diseaseGeneHeme Oxygenase-1 and Carbon MonoxideBiomedical Research and PathophysiologyInflammasome and immune disorders