Rhodium-catalyzed regioselective C–H activation/Lossen rearrangement/annulation for the green synthesis of trisubstituted 2-pyridones
Yidi Li, Huiying Xu, Lin Huang, Zhi Zhou, Zhenhao Tang, Haifang Meng, Wei Zhang, Wei Yi, Xiaowei Wu
Abstract
A green and novel approach for the synthesis of 2-pyridone derivatives by a rhodium-catalyzed C–H activation/Lossen rearrangement of acrylamides and propargyl alcohols is reported.
Topics & Concepts
ChemistryAnnulationRegioselectivityRhodiumPropargylCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms