Silver‐Enabled General Radical Difluoromethylation Reaction with TMSCF<sub>2</sub>H
Jun Yang, Shengqing Zhu, Fang Wang, Feng‐Ling Qing, Lingling Chu
Abstract
Abstract A silver‐mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF 2 H is reported for the first time. This method enables direct and facile access to CF 2 H‐alkenes from abundant alkenes with excellent functional‐group compatibility. Moreover, this Ag/TMSCF 2 H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C−CF 2 H bonds.
Topics & Concepts
Compatibility (geochemistry)ChemistryCombinatorial chemistryComputer scienceNanotechnologyMaterials scienceChemical engineeringEngineeringFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds