Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer–water exchange
Trishna Rajbongshi, Kashyap Kumar Sarmah, Susobhan Das, Poonam Deka, Arijit Saha, Binoy K. Saha, Horst Puschmann, C. Malla Reddy, Ranjit Thakuria
Abstract
The cocrystallisation of carbamazepine (CBZ) with 3,4-/3,5-dihydroxybenzoic acids (34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation between the mechanical properties of the CBZ-DHBA cocrystals with the amount of coformer present.
Topics & Concepts
IsostructuralCocrystalStoichiometryChemistryMoleculeCarbamazepineInorganic chemistryCombinatorial chemistryOrganic chemistryHydrogen bondCrystal structureNeuroscienceBiologyEpilepsyCrystallography and molecular interactionsCrystallization and Solubility StudiesPhenothiazines and Benzothiazines Synthesis and Activities