Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO <sub>2</sub>
Terry Shing‐Bong Lou, Yu Kawamata, Tamara El‐Hayek Ewing, Guillermo A. Correa‐Otero, Michael R. Collins, Phil S. Baran
Abstract
Abstract Simple access to aryl sulfinates from aryl iodides and bromides is reported using an inexpensive Ni‐electrocatalytic protocol. The reaction exhibits a broad scope, uses stock solution of simple SO 2 as sulfur source, and can be scaled up in batch and recycle flow settings. The limitations of this reaction are clearly shown and put into context by benchmarking with state‐of‐the‐art Pd‐based methods.
Topics & Concepts
NickelHalideArylScalabilityChemoselectivityChemistryCombinatorial chemistryComputer scienceCatalysisOrganic chemistryDatabaseAlkylSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsRadical Photochemical Reactions