Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction
Alan J. Mouton, Nikaela Aitken, Jemylle G. Morato, Katherine R. O’Quinn, Jussara M. do Carmo, Alexandre A. da Silva, Ana Carolina Mieko Omoto, Xuan Li, Zhen Wang, Alexandra C. Schrimpe‐Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Joshua Stanford, Jordan Brown, John E. Hall
Abstract
Glutamine metabolism is altered in both infarct macrophages and the remote left ventricle (LV) following myocardial infarction (MI). Supplemental glutamine improves LV function following MI while inhibiting glutamine metabolism with BPTES worsens LV function. Supplemental glutamine or BPTES does not impact macrophage immunometabolic phenotypes after MI.
Topics & Concepts
Myocardial infarctionInflammationMacrophageGlutamineVentricular functionCardiologyInternal medicineMedicineVentricular remodelingMetabolismChemistryBiochemistryIn vitroAmino acidDiet and metabolism studiesMetabolomics and Mass Spectrometry StudiesLiver Disease Diagnosis and Treatment