Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury
Sophia M. Sears, Joanna L. Feng, Andrew Orwick, Alexis A. Vega, Austin Krueger, Parag P. Shah, Mark A. Doll, Levi J. Beverly, Leah J. Siskind
Abstract
This study examined how inhibition of autophagy has opposite effects on the development of acute and chronic kidney injury. Autophagy inhibition exacerbated the development of acute kidney injury following a single high dose of cisplatin but prevented the development of injury and fibrosis following repeated low doses of cisplatin.
Topics & Concepts
CisplatinNephrotoxicityMedicineAcute kidney injuryPharmacologyKidneyAutophagyRenal functionFibrosisInflammationDosingChemotherapyInternal medicineBiologyApoptosisBiochemistryChemotherapy-induced organ toxicity mitigationAcute Lymphoblastic Leukemia researchPharmacological Effects and Toxicity Studies