Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation
Prerona Bora, Suman Manna, Mrutyunjay A. Nair, Rupali R. M. Sathe, Shubham Singh, Venkata Sai Sreyas Adury, Kavya Gupta, Arnab Mukherjee, Deepak Kumar Saini, Siddhesh S. Kamat, Amrita B. Hazra, Harinath Chakrapani
Abstract
A persulfide/hydrogen sulfide generation strategy through artificial substrates for 3-mercaptopyruvate sulfurtransferase (3-MST) is reported, which enhances cellular persulfides, attenuates reactive oxygen species (ROS), and alleviates inflammation.
Topics & Concepts
SulfurtransferaseSubstrate (aquarium)ChemistryNeuroinflammationHydrogen sulfideEnzymeReactive oxygen speciesInflammationBiochemistrySulfurBiologyOrganic chemistryEcologyCysteineImmunologySulfur Compounds in BiologyAdenosine and Purinergic SignalingEicosanoids and Hypertension Pharmacology