Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration
Román Serrat, Ana Covelo, Vladimir Kouskoff, Sébastien Delcasso, Andrea Ruiz-Calvo, Nicolas Chenouard, Carol Stella, Corinne Blancard, Bénédicte Salin, Francisca Julio‐Kalajzić, Astrid Cannich, Federico Massa, Marjorie Varilh, Séverine Deforges, Laurie M. Robin, Diego De Stefani, Arnau Busquets-García, Frédéric Gambino, Anna Beyeler, Sandrine Pouvreau, Giovanni Marsicano
Abstract
receptors or dominant-negative MCU expression in astrocytes blocks lateral synaptic potentiation, through which astrocytes integrate the activity of distant synapses. Altogether, these data reveal an endocannabinoid link between astroglial MERCs and the regulation of brain network functions.
Topics & Concepts
Synaptic plasticityCell biologyCalcium signalingBiologyEndocannabinoid systemNeuroscienceMitochondrionNeurotransmissionLong-term potentiationEndoplasmic reticulumAstrocyteSignal transductionReceptorBiochemistryCentral nervous systemNeuroscience and Neuropharmacology ResearchCannabis and Cannabinoid ResearchIon channel regulation and function