Age-Related Changes in Extracellular Matrix
Zulfiia G. Guvatova, Pavel V. Borisov, Alexey Alekseev, Alexey Moskalev
Abstract
Extracellular matrix (ECM) is an extracellular tissue structure that, in addition to mechanical support to the cell, is involved in regulation of many cellular processes, including chemical transport, growth, migration, differentiation, and cell senescence. Age-related changes in the structure and composition of the matrix and increase of ECM stiffness with age affect functioning of many tissues and contribute to the development of various pathological conditions. This review considers age-related changes of ECM in various tissues and organs, in particular, effect of ECM changes on aging is discussed.
Topics & Concepts
Extracellular matrixCell biologySenescenceExtracellularCellular senescencePathologicalMatrix (chemical analysis)BiologyChemistryPathologyMedicineBiochemistryPhenotypeChromatographyGeneAdvanced Glycation End Products researchTissue Engineering and Regenerative MedicineWound Healing and Treatments