SnS<sub>2</sub> QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma
Zhenrun Li, Zihui Liang, Peilin Wang, Wenyan Li, Yameng Li, Ning Liu, Qiang Ma
Abstract
This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS 2 QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.76 times. Furthermore, the self-assembled surface plasmonic Bi@SiO 2 array was prepared. When the ECL of SnS 2 QDs@MXene resonated with the electronic oscillations in the Bi@SiO 2 NPs array, the luminescence intensity was enhanced and regulated into the directionally polarized signal by the SPC-ECL effect. Remarkably, the detection of CD9-exosomes in saliva was achieved successfully based on the above sensing system, which can be used to analysis the acute exacerbation and chronic persistence of childhood asthma.