HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer
Bei Liu, Jiaxi Zhang, Xue Meng, Shelly M. Xie, Fang Liu, Heli Chen, Demin Yao, Minglei Li, Minghui Guo, Haitao Shen, Xianghong Zhang, Lingxiao Xing
Topics & Concepts
mTORC1BiologyTSC2Cancer researchCell biologyRHEBPI3K/AKT/mTOR pathwayStress granuleCancer cellmTORC2LymphangioleiomyomatosisCancerSignal transductionBiochemistryInternal medicineGeneticsGeneLungMedicineMessenger RNATranslation (biology)Histone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsUbiquitin and proteasome pathways