PPy nanoneedle based nanoplatform capable of overcoming biological barriers for synergistic chemo-photothermal therapy
Yanyan Yin, Yutong Hao, Ning Wang, Pengfei Yang, Na Li, Xiaoyi Zhang, Yu Song, Xuebing Feng, Weiwei Ma
Abstract
the nuclear pore complex by passive diffusion. With the ability of overcoming biological barriers, the PPy nanoneedle based nanoplatform would deliver drugs into the organelles more effectively. Under near infrared (NIR) laser irradiation, PPy as the photothermal agent could lead to tumor cellular structure damage for photothermal therapy (PTT). Therefore, PPy-HA@DOX developed here would exploit the merits of synergistic combination of chemo-photothermal therapy, which would pave the way toward more effective nanotherapeutics.
Topics & Concepts
Photothermal therapyNanoneedleNanotechnologyDoxorubicinEndocytosisDrug deliveryIn vivoPhotothermal effectBiophysicsNanomedicineMaterials scienceChemistryCellNanoparticleNanostructureChemotherapyMedicineBiochemistrySurgeryBiotechnologyBiologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryExtracellular vesicles in disease