Discovery of novel coumarin-based derivatives as inhibitors of tubulin polymerization targeting the colchicine binding site with potent anti-gastric cancer activities
Xin-Yi Tian, Weixin Zhang, Xiao-Yu Chen, Mei-Qi Jia, Sai‐Yang Zhang, Yifan Chen, Shuo Yuan, Jian Song, Jia Li
Topics & Concepts
TubulinChemistryCoumarinPharmacophoreMicrotubuleColchicineDocking (animal)Microtubule polymerizationApoptosisCancer cellStereochemistryBinding siteIC50In vitroBiochemistryCancerCell biologyBiologyGeneticsOrganic chemistryNursingMedicineSynthesis and biological activitySynthesis and Biological EvaluationClick Chemistry and Applications