Post-Viral Pain, Fatigue, and Sleep Disturbance Syndromes: Current Knowledge and Future Directions
Caleb Tackey, P. Maxwell Slepian, Hance Clarke, Nimish Mittal
Abstract
Background: Post-viral pain syndrome, also known as post-viral syndrome, is a complex condition characterized by persistent pain, fatigue, musculoskeletal pain, neuropathic pain, neurocognitive difficulties, and sleep disturbances that can occur after an individual has recovered from a viral infection.Aims: This narrative review provides a summary of the sequelae of post-viral syndromes, viral agents that cause it, and the pathophysiology, treatment, and future considerations for research and targeted therapies.Methods: Medline, PubMed, and Embase databases were used to search for studies on viruses associated with post-viral syndrome.Conclusion: Much remains unknown regarding the pathophysiology of post-viral syndromes, and few studies have provided a comprehensive summary of the condition, agents that cause it, and successful treatment modalities.With the COVID-19 pandemic continuing to affect millions of people worldwide, the need for an understanding of the etiology of post-viral illness and how to help individuals cope with the sequalae is paramount. RSUM Contexte:Le syndrome de la douleur post-virale, galement connu sous le nom de syndrome postviral, est une affection complexe caractrise par des douleurs persistantes, de la fatigue, des douleurs musculosquelettiques, des douleurs neuropathiques, des difficults neurocognitives et des troubles du sommeil qui peuvent survenir aprs la gurison d'une infection virale.Objectifs: Cette revue narrative prsente un rsum des squelles des syndromes post-viraux, des agents viraux qui les causent, ainsi que de la pathophysiologie, des traitements et des considrations futures pour la recherche et les traitements cibls.Mthodes utilises: Les bases de donnes Medline, PubMed et Embase ont t utilises pour rechercher des tudes sur les virus associs au syndrome post-viral.Conclusion: La physiopathologie des syndromes post-viraux reste largement mconnue et peu d'tudes ont prsent un rsum complet de l'affection, des agents qui la provoquent et des modalits de traitement efficaces.Alors que la pandmie de COVID-19 continue d'affecter des millions de personnes dans le monde, il est primordial de comprendre l'tiologie de la maladie postvirale et de savoir comment aider les individus faire face aux squelles.