Transcriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells
Daria S. Kostyunina, Nikolai V. Pakhomov, Amina Jouida, Eugène Dillon, John A. Baugh, Paul McLoughlin
Abstract
There is marked sexual dimorphism in the development and progression of pulmonary hypertension. We show differences in RNA and protein expression between female and male human pulmonary microvascular endothelial cells grown under conditions of physiological shear stress, which identify sex-different cellular pathways both in normoxia and hypoxia. Importantly, these differences were detected in the absence of sex hormone differences. The pathways identified may provide novel targets for the development of sex-specific therapies.
Topics & Concepts
BiologyTranscriptomeProteomicsCell biologyComputational biologyGene expressionGeneGeneticsPulmonary Hypertension Research and TreatmentsRenin-Angiotensin System StudiesSex and Gender in Healthcare