Hypoxia-sensitive micellar nanoparticles for co-delivery of siRNA and chemotherapeutics to overcome multi-drug resistance in tumor cells
Ujjwal Joshi, Nina Filipczak, Muhammad Muzamil Khan, Sara Aly Attia, Vladimir P. Torchilin
Topics & Concepts
CytotoxicityHeLaDoxorubicinNanoparticleBiophysicsDrug deliveryTumor hypoxiaCancer cellMultiple drug resistancePEG ratioCell cultureChemistrySpheroidHypoxia (environmental)CellIn vitroMaterials scienceCancer researchNanotechnologyBiologyCancerMedicineBiochemistryChemotherapyOxygenAntibioticsRadiation therapyInternal medicineEconomicsFinanceGeneticsOrganic chemistryRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics