Manganese(<scp>ii</scp>) promotes prebiotically plausible non-enzymatic RNA ligation reactions
Ziwei Liu, Clancy Zhijian Jiang, Andrew D. Bond, Nicholas J. Tosca, John D. Sutherland
Abstract
Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.
Topics & Concepts
ReagentLigationManganeseChemistryRNAYield (engineering)EnzymeCombinatorial chemistryChemical ligationBiochemistryMolecular biologyBiologyOrganic chemistryMaterials scienceGeneMetallurgyOrigins and Evolution of LifeRadioactive element chemistry and processingAmino Acid Enzymes and Metabolism