Stereospecific cyanation of the olefinic C–H bond enabled by 1,4-rhodium migration
Xiaosa Lu, Yinhua Huang
Abstract
Rhodium-catalyzed stereospecific cyanation of the olefinic C–H bond for the synthesis of <italic>β,β</italic>-disubstituted acrylonitriles has been developed.
Topics & Concepts
CyanationChemistryStereospecificityRhodiumStereochemistryMedicinal chemistryCatalysisOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions