A new lactone from mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-A9
Wenxiu Zhang, Lili Hao, Xiaoya Qin, Jiguo Huang, Rui‐Yun Yang, Jun Li, Xishan Huang
Abstract
A new lactone, asperlactone A (1), and four known lactone derivatives 2–5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. Their structures were elucidated based on high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of 1 was established. Compounds 1–5 were evaluated for their anti-inflammatory activities against nitric oxide (NO) production, and compounds 1–5 showed moderate inhibitory activities with IC50 values ranging from 15.87 to 30.48 µM.