Cost-effectiveness of <sup>18</sup>F-FET PET for early treatment response assessment in glioma patients following adjuvant temozolomide chemotherapy
Jurij Rosen, Garry Ceccon, Elena K. Bauer, Jan‐Michael Werner, Caroline Tscherpel, Veronika Dunkl, Marion Rapp, Michael Sabel, Ulrich Herrlinger, Alexander Heinzel, Niklaus Schaefer, Maximilian I. Ruge, Roland Goldbrunner, Gabriele Stoffels, Christoph Kabbasch, Gereon R. Fink, Karl‐Josef Langen, Norbert Galldiks
Abstract
<h3>Abstract</h3> The sensory response threshold is a fundamental biophysical property of biological systems that underlies many physiological and computational functions, and its systematic study has played a pivotal role in uncovering the principles of neural computation. Here, we show that ant colonies, which perform computational tasks at the group level, have emergent collective sensory response thresholds. Colonies respond collectively to step changes in temperature and evacuate the nest during severe perturbations. This response is characterized by a group-size dependent threshold, and the underlying dynamics are dominated by social feedback between the ants. Using a binary network model, we demonstrate that a balance between short-range excitatory and long-range inhibitory interactions can explain the emergence of the collective response threshold and its size dependency. Our findings illustrate how simple social dynamics allow insect colonies to integrate information about the external environment and their internal state to produce adaptive collective responses.