Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives
Igor V. Bibik, E. Yu. Bibik, В. В. Доценко, К. А. Фролов, С. Г. Кривоколыско, Nicolai A. Aksenov, И. В. Аксенова, С. В. Щербаков, S. N. Ovcharov
Abstract
Abstract The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics.
Topics & Concepts
ChemistryAnalgesicAlkylationKetorolacIn vivoOrganic chemistryCombinatorial chemistryPharmacologyCatalysisMedicineBiologyBiotechnologySynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Characterization of Heterocyclic Compounds