Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
Duygu Gezen‐Ak, Zuhal Yurttaş, Tugay Çamoğlu, Erdinç Dursun
Abstract
The amyloid β (Aβ) and the α-synuclein (α-syn) are shown to be translocated into mitochondria. Even though their roles are widely investigated in pathological conditions, information on the presence and functions of Aβ and α-syn in mitochondria in endogenous levels is somewhat limited. We hypothesized that endogenous Aβ fragments or α-syn could interact with mitochondrial DNA (mtDNA) directly or influence RNAs or transcription factors in mitochondria and change the mtDNA transcription profile. In this review, we summarized clues of these possible interactions.
Topics & Concepts
Mitochondrial DNAMitochondrionEndogenyBiologyTranscription (linguistics)DNAGeneticsCell biologyHuman mitochondrial geneticsGeneBiochemistryLinguisticsPhilosophyAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology