Manno-oligosaccharides from cassia seed gum ameliorate inflammation and improve glucose metabolism in diabetic rats
Chenxuan Wu, Jun Liu, Yanxiao Li, Nannan Wang, Qiaojuan Yan, Zhengqiang Jiang
Abstract
associated inflammasome activation in the intestine and liver with glucose metabolism disorder was inhibited by CMOS, resulting in reduced interleukin-1β secretion (by 38.8-46.4% for CMOS of 300-1200 mg per kg b.w. per d) and inflammation. Furthermore, CMOS regulated the AKT/IRS/AMPK signaling pathway and improved glucose metabolism in the liver. Findings obtained here implicated that CMOS could modulate metabolic-inflammation as a functional dietary supplement.
Topics & Concepts
StreptozotocinEndocrinologyChemistryInternal medicineDiabetes mellitusCecumGlucose transporterInsulinBiologyMedicineGut microbiota and healthMicrobial Metabolites in Food BiotechnologyDiet, Metabolism, and Disease