Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome
Josiane F. Silva, Vânia Cláudia Olivon, Fabíola Mestriner, Camila Ziliotto Zanotto, Raphael Gomes Ferreira, Nathanne S. Ferreira, Carlos Alberto Aguiar Silva, João Paulo Mesquita Luiz, Juliano Alves, Rubens Fazan, Fernando Q. Cunha, José C. Alves‐Filho, Rita C. Tostes
Abstract
-GlcNAc reduces systemic inflammation and cardiovascular disfunction in experimental sepsis models, pointing this pathway as a potential target for therapeutic intervention.
Topics & Concepts
Systemic inflammatory response syndromeSepsisSystemic inflammationLipopolysaccharideMedicineInflammationTumor necrosis factor alphaPhenylephrineProinflammatory cytokineImmunologySeptic shockInternal medicineEndocrinologyBlood pressureImmune Response and InflammationAdvanced Glycation End Products researchGlycosylation and Glycoproteins Research