Trifluoperazine mitigates cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in mice by modulating the AKT/mTOR-driven autophagy and Nrf2/HO-1 signaling cascades
Ahmed K. Saleh, Nageh Ahmed El‐Mahdy, Thanaa A. El‐Masry, Aya H. El-Kadem
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayProtein kinase BOxidative stressTrifluoperazineChemistryPharmacologyApoptosisBiologyBiochemistryCalmodulinEnzymeChemotherapy-induced organ toxicity mitigationDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology