SIRPα sequesters SHP-2 to promote IL-4 and IL-13 signaling and the alternative activation of macrophages
Lei Shi, Koby Kidder, Zhen Bian, Samantha Kuon Ting Chiang, Corbett Ouellette, Yuan Liu
Abstract
macrophages. These studies reveal a previously unappreciated role for SIRPα in promoting IL-4 and IL-13 signaling and reveal the mechanistic basis by which SIRPα enhances the alternative activation of macrophages.
Topics & Concepts
PhosphorylationCell biologyTyrosine phosphorylationSignal transductionBiologyImmunoreceptor tyrosine-based activation motifSH2 domainGalectins and Cancer BiologyPhagocytosis and Immune RegulationImmune cells in cancer