Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury
Jie Cen, Haiying Zhu, Chenggang Hong, Feng Zhang, Shuangrong Liu, Bo Yang, Yongping Yu, Yuanmei Wen, Ji Cao, Wenteng Chen
Topics & Concepts
Acute kidney injuryChemistryRhabdomyolysisKidneyPharmacologyReactive oxygen speciesToxicityDeferoxamineApoptosisIn vivoTherapeutic indexHypoxia (environmental)Downregulation and upregulationDeferiproneBiochemistryOxygenMedicineInternal medicineDrugBiologyGeneBiotechnologyOrganic chemistryIron Metabolism and DisordersTrace Elements in HealthErythropoietin and Anemia Treatment