A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli
Mallory Wright, Mandeep Kaur, Laura K. Thompson, Georgina Cox
Abstract
Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This review highlights key discoveries over the past six decades and emphasizes the remaining gaps in understanding how TolC contributes to physiological functions in E. coli.
Topics & Concepts
Escherichia coliPerspective (graphical)Bacterial outer membraneChannel (broadcasting)Escherichia coli ProteinsChemistryComputer scienceBiochemistryGeneComputer networkArtificial intelligenceEscherichia coli research studiesBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria