Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway
Yi Hou, Chao Pi, Xianhu Feng, Yuanyuan Wang, Shaozhi Fu, Xiaomei Zhang, Ling Zhao, Yumeng Wei
Abstract
showed that BAL had higher antitumor activity than did BAD and BA, which were related to promotion of the apoptosis of tumor cells by inhibiting the expression of p-Akt on PI3K/Akt pathway. This study provides an experimental basis for the development of a new configuration of BA for the treatment of cancer.
Topics & Concepts
PI3K/AKT/mTOR pathwayIn vivoApoptosisProtein kinase BBaicalinIn vitroChemistrySignal transductionCell biologyPharmacologyBiochemistryBiologyGeneticsHigh-performance liquid chromatographyChromatographyFlavonoids in Medical ResearchNatural product bioactivities and synthesisBioactive natural compounds