The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
Henny Maat, Tjerk Jan Atsma, Shanna M. Hogeling, Aida Rodríguez López, Jennifer Jaques, Mirjam Olthuis, Marcel P. de Vries, Chantal Gravesteijn, Annet Z. Brouwers-Vos, Nisha van der Meer, Suzan Datema, Jonas B. Salzbrunn, Gerwin Huls, Roy Baas, Joost H.A. Martens, Vincent van den Boom, Jan Jacob Schuringa
Abstract
in human leukemia xenografts. We propose a model where USP7 counteracts TRIM27 E3 ligase activity, thereby maintaining PRC1.1 integrity and function. Moreover, USP7 inhibition may be a promising new strategy to treat AML patients.
Topics & Concepts
DruggabilityFunction (biology)LeukemiaBiologyComputational biologyCell biologyChemistryGeneticsGeneUbiquitin and proteasome pathwaysinterferon and immune responsesCytomegalovirus and herpesvirus research