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Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents

Xin Chen, Hongyu Zhu, Xuequan liu, Qihong Li, Mingxin Dong

2023Bioorganic & Medicinal Chemistry11 citationsDOI

Topics & Concepts

NeuroprotectionNMDA receptorAllosteric regulationExcitotoxicityChemistryGlutamate receptorAllosteric modulatorPharmacologyIn vivoNeuroscienceReceptorBiochemistryBiologyBiotechnologyNeuroscience and Neuropharmacology ResearchMolecular Sensors and Ion DetectionIon channel regulation and function
Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents | Litcius