Preparation of quercetin–nicotinamide cocrystals and their evaluation under <i>in vivo</i> and <i>in vitro</i> conditions
Na Wu, Yan Zhang, Jian Ren, Aiguo Zeng, Juntian Liu
Abstract
experiments suggested that quercetin-nicotinamide cocrystals could significantly increase the oral absorption of quercetin by nearly 4-fold. These results demonstrate that the developed quercetin-nicotinamide cocrystals are a promising oral formulation toward improvement in the dissolution and bioavailability of quercetin.
Topics & Concepts
QuercetinNicotinamideBioavailabilityChemistryCocrystalDissolutionNuclear chemistryChromatographyOrganic chemistryHydrogen bondMoleculePharmacologyAntioxidantMedicineEnzymeCrystallography and molecular interactionsCrystallization and Solubility StudiesChemical Thermodynamics and Molecular Structure