Synthesis, chemical characterization and DNA interaction study of new diclofenac and ibuprofen zinc (II)-nicotinamide ternary complexes as cyclooxygenase inhibitor prototypes
Paulo Roberto dos Santos, Claus Tröger Pich, Davi F. Back, Franco Smiderle, Françoise Dumas, Sidnei Moura
Topics & Concepts
ChemistryZincNicotinamideMoleculeDNALigand (biochemistry)Circular dichroismStereochemistryTernary complexCombinatorial chemistryNuclear chemistryOrganic chemistryEnzymeBiochemistryReceptorMetal complexes synthesis and propertiesInflammatory mediators and NSAID effectsSynthesis and Biological Evaluation