Organomercury Nucleic Acids: Past, Present and Future
Dattatraya Uttam Ukale, Tuomas Lönnberg
Abstract
Abstract Synthetic efforts towards nucleosides, nucleotides, oligonucleotides and nucleic acids covalently mercurated at one or more of their base moieties are summarized, followed by a discussion of the proposed, realized and abandoned applications of this unique class of compounds. Special emphasis is given to fields in which active research is ongoing, notably the use of Hg II ‐mediated base pairing to improve the hybridization properties of oligonucleotide probes. Finally, this minireview attempts to anticipate potential future applications of organomercury nucleic acids.
Topics & Concepts
Nucleic acidOligonucleotideNucleotideChemistryComputational biologyCombinatorial chemistryNanotechnologyBiochemistryBiologyDNAMaterials scienceGeneDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion Detection