BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium
Maria C. Lucana, Roberta Lucchi, Fabien Gosselet, Cristina Díaz‐Perlas, Benjamí Oller‐Salvia
Abstract
Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.
Topics & Concepts
PeptidomimeticBlood–brain barrierPeptideChemistryBiophysicsEndotheliumNeuroscienceBiochemistryBiologyCentral nervous systemEndocrinologyAdvanced biosensing and bioanalysis techniquesChemical Synthesis and AnalysisSupramolecular Self-Assembly in Materials