Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry
Dongxia Wang, Jakub Baudys, Jonathan L. Bundy, Maria I. Solano, Theodore R. Keppel, John R. Barr
Abstract
(SF9) insect cells. These results provide useful information for the study of the interactions of SARS-CoV-2 viral proteins and for the development of effective vaccines and therapeutics.
Topics & Concepts
EctodomainChemistryGlycosylationGlycanProtein subunitSf9SpodopteraCoronavirusRecombinant DNAHEK 293 cellsMass spectrometryBiochemistryGlycoproteinReceptorGeneCoronavirus disease 2019 (COVID-19)ChromatographyDiseaseInfectious disease (medical specialty)MedicinePathologyInfluenza Virus Research StudiesSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches